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However, following ingestion of a large overdose (150 mg/kg or greater) the glucuronide and sulfate conjugation pathways are saturated resulting in a larger fraction of the drug being metabolized via the P-450 pathway

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Aducanumab ( 1 ), lecanemab ( 2 ), and donanemab ( 10 ) are monoclonal antibodies targeting A, each of which has met with differing outcomes: Aducanumab ( 1 ) 416,417 received controversial FDA accelerated approval in 2021

Evaluation of copper chelation therapy in a transgenic rat model of cerebral amyloid angiopathy

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